Programme 2019

Programme

Friday: October 11, 2019

18:30-20:00

Welcome Reception

Location: Lower Pool Deck

Saturday: October 12, 2019

07:30-08:00

Breakfast

Location: Isles Rooms

08:00

Meeting Registration

Location: Sevilla Foyer

08:15-09:15

Introduction & Meeting Objectives

John Gribben & David Maloney

  • T-cell biology; John Gribben
  • Leveling the field in CAR-T – where are we now?; David Maloney

09:15-11:00

Session I:  CAR-T in ALL

Chairs: Noelle Frey & Bijal Shah

  • CAR-T in pediatric ALL; Rebecca Gardner
  • CAR-T in adult ALL; Claire Roddie
  • Bi-specific CAR T-cell therapies/onsite manufacturing; Nirav Shah 
  • The role of consolidative ALLO SCT; Noelle Frey
  • Future directions for CAR-T therapy in ALL; Bijal Shah

Panel Discussion

11:00-11:15

Coffee Break

11:15-12:30

Session II: CAR-T in CLL

Chairs: John Gribben & Saar Gill

  • CAR-T in the era of ibrutinib, rituximab & venetoclax; Saar Gill
  • Update CLL CAR-T trial landscape; Tanya Siddiqi
  • Definition of response and resistance to CART19 in CLL; Joseph Fraietta
  • Combinations in CAR T-cell therapy in R/R CLL; Jordan Gauthier

Panel discussion

12:30-13:30

Lunch

Location: Isles Rooms

13:30-16:00

Session III:  CAR-T in Lymphoma

Chairs: Caron Jacobson & Steve Schuster

  • Tisangenlecleucel; Steve Schuster
  • Axicabtagene ciloleucel in DLBCL; Fred Locke
  • Lisocabtagene maraleucel in DLBCL; Caron Jacobson
  • Industry talk; Peter Emtage, Kite

Roundtable Discussion

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  • CAR T-cell approaches to T-cell lymphoma; Matthew Frigault
  • CAR-T vs Transplant; Ian Flinn
  • CAR-T in follicular lymphoma; Loretta Nastoupil
  • CD5 and CD7 CAR-T cells; Rayne Rouce / LaQuisa Hill
  • CD19-CAR-T overview; Elise Chong

Roundtable Discussion

16:00-17:30

Session IV: Toxicity Issues with CAR-T

Chairs: Bianca Santomasso & Noelle Frey

  • Consensus grading scale for CRS and neurotoxicity; Daniel Lee
  • Optimization of CRS management (fractionated dosing, inverse dose/disease burden, other anticytokine targets); Rebecca Gardner
  • Neurotoxicity; Bianca Santomasso

Roundtable Discussion

19:00

1st iwCAR-T DINNER

Location: Ole Restaurant (located onsite at the Intercontinental Hotel)

Sunday: October 13, 2019

08:00-08:30

Breakfast

Location: Isles Rooms

08:30-09:30

Session V:  Overcoming Mechanisms of Resistance to CAR Therapy

Chairs: Scott Rodig

  • Immunosuppressive features of the TME; Scott Rodig
  • Mechanisms of resistance to CAR therapy; Nirali Shah
  • Persistence/exhaustion; TBC

Panel Discussion

09:30-10:45

Session VI: CAR-T in AML

Chairs: Saar Gill & Elizabeth Budde

  • Will CAR T-cell therapy have a role in AML? Potential and pitfalls; Saar Gill
  • AML for CAR-T – targeting CD123; Elizabeth Budde
  • NKG2D/CYAD-01; Marco Davila
  • Compound CAR-T (CLL1b-CD33b compound CAR); Fang Liu
  • Cell therapy development for myeloid diseases: balancing efficacy and toxicity; Marco Davila

Panel Discussion

10:45-11:00

Coffee Break

11:00-13:00

Session VII: CAR-T in Myeloma

Chairs: Yi Lin & Ed Stadtmauer

  • BCMA CAR-T (bb2121 & bb21217); Yi Lin
  • BCMA CAR-T (JACRH125); Sham Mailankody
  • Dual epitope-binding CAR-T – LCAR-B38M; Wan-Hong Zhao
  • NY-ESO-1 CRISP edited TCR; Ed Stadtmauer
  • SlamF7 CARs; Krina Patel
  • Novel targets and therapies in CAR-T; Hardik Jetani
  • JNJ-68284528 – focus on perspective of global CAR-T development; Jordan Schecter (J&J) & Tonia Nesheiwat (Legend)

Panel Discussion

13:00-13:30

Lunch

Location: Isles Rooms

13:30-14:45

Session VIII: Evolution of cellular therapies

Chairs: David Maloney & Fred Locke

  • Allogeneic CAR-Ts; Reuben Benjamin
  • CD30; Barbara Savaldo
  • TCR like antibody CARs (recognizing peptide MHC molecules); William Go
  • CAR constructs into cells other than T-cells (NK); David Maloney

Panel Discussion

14:45-15:00

Final Meeting Summary & Conclusions

iwCAR-T Committee

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Location

The Scottsdale Plaza Resort,
7200 North Scottsdale Road,
Paradise Valley,
Scottsdale, AZ 85253

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